Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain

@article{McGeary2011EffectsON,
  title={Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain},
  author={John E. McGeary and Volkan Gurel and Valerie S. Knopik and James Spaulding and John McMichael},
  journal={Neuropeptides},
  year={2011},
  volume={45},
  pages={317-322}
}
Evidence suggests that nerve growth factor (NGF) may have antidepressant properties but the pharmacological mechanisms remain unknown. Previously, we found that NGF improved performance in the forced swim test in Flinders Sensitive Line rats, but did not appear to have similar biochemical actions with the antidepressant fluoxetine. Gene expression profiles for neurotransmitter receptors and regulator-related genes in the amygdala/hippocampus were determined in rats treated for 14days with NGF… 
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NGF, BDNF and Arc mRNA Expression in the Hippocampus of Rats After Administration of Morphine
TLDR
It is found that a single dose of morphine at the highest dose of 20 mg/kg decreases the post-training step-through-latency, while repeated administration of the same dose for 15 successive days increases this indicator of memory retrieval.
Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain
TLDR
Findings of reduced expression of BDNF, TrkB, NGF, and TrkA on both the protein and mRNA levels of postmortem brains of suicide victims suggest that these molecules may play an important role in the pathophysiological aspects of suicidal behavior.
Time Course of Behavioral Alteration and mRNA Levels of Neurotrophic Factor Following Stress Exposure in Mouse
TLDR
It is demonstrated that chronic stress exposure induces prolonged BDNF and NGF mRNA changes and increases corticosterone levels and depression-like behavior in the FST, but does not alter other neurotrophic factors or performance in the sucrose preference test.
Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse
This review discusses the impact of neurotrophins and other trophic factors, including fibroblast growth factor and glial cell line-derived neurotrophic factor, on mood disorders, weight regulation…
Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment
TLDR
Some of the preclinical and clinical studies aimed at disclosing the role of BDNF and NGF mediated pathophysiological mechanisms of depression and the new therapeutic approaches targeting those key molecules are reviewed.
Nerve growth factor in the psychiatric brain.
The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a…
Impact of NGF signaling on neuroplasticity during depression: Insights in neuroplasticity-dependent therapeutic approaches
TLDR
NGF modulation might provide more insights into understanding the role of neuroplasticity in the pathophysiology of depression and help in efficient targeted treatment strategies for depression in the future.
Harm avoidance involved in mediating the association between nerve growth factor (NGF) gene polymorphisms and antidepressant efficacy in patients with major depressive disorder.
TLDR
NGF variants are associated with remission rates after 8-week antidepressant treatment, and harm avoidance partially mediated the effect of NGF variants on treatment outcomes.
Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders.
TLDR
Focusing on the role of these growth factors and their relationship with the main impairments (cognitive, emotional and social) of these pathologies, some of these signaling molecules may be suitable biological markers for diagnosis and prognosis in cognitive, mood and social disabilities across different mental disorders.
The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma
TLDR
The current understanding of the NGF signaling in retina and the therapeutic implications in the treatment of glaucoma are discussed.
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