Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain

@article{McGeary2011EffectsON,
  title={Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain},
  author={John E. McGeary and Volkan Gurel and Valerie S. Knopik and James Spaulding and John McMichael},
  journal={Neuropeptides},
  year={2011},
  volume={45},
  pages={317-322}
}

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References

SHOWING 1-10 OF 41 REFERENCES
Nerve growth factor (NGF) has novel antidepressant-like properties in rats
cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs
TLDR
A significant number and homology in gene expression were observed with the three antidepressants and many of the genes were associated with neurogenesis and synaptogenesis, including synaptophysin and neogenin.
Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusers
Intranasal Administration of Nerve Growth Factor Produces Antidepressant-Like Effects in Animals
Many works showed that nerve growth factor (NGF) injected into the brain of animal model emerges potential antidepressant effects. However, this route of administration significantly restricts the
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
TLDR
The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.
Anxiolytic and antidepressant actions of somatostatin: the role of sst2 and sst3 receptors
TLDR
The results suggest a clinical role for somatostatin agonists for the simultaneous treatment of anxiety and depression, which are often comorbid.
New insights into BDNF function in depression and anxiety
TLDR
BDNF may be a target of antidepressants, but not the sole mediator of depression or anxiety, and as the precursor proBDNF and the mature protein mBDNF can elicit opposite effects on cellular functions, the impact of proBD NF and its cleavage on mood should be considered.
Possible role of nerve growth factor in the pathogenesis of alcohol dependence.
TLDR
The study suggests that the NGF levels may be a trait marker for the development of alcohol dependence.
Antidepressant-elicited changes in gene expression Remodeling of neuronal circuits as a new hypothesis for drug efficacy
...
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2
3
4
5
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