Effects of neonatally administered low-dose diethylstilbestrol on the induction of mammary carcinomas and dysplasias induced by 7,12-dimethylbenz [a] anthracene in female rats.

@article{Yoshikawa2008EffectsON,
  title={Effects of neonatally administered low-dose diethylstilbestrol on the induction of mammary carcinomas and dysplasias induced by 7,12-dimethylbenz [a] anthracene in female rats.},
  author={Tsuyoshi Yoshikawa and Hiroaki Kawaguchi and Yoshihisa Umekita and Masakazu Souda and Kentaro Gejima and Hideo Kawashima and Ryoichi Nagata and Hiroki Yoshida},
  journal={In vivo},
  year={2008},
  volume={22 2},
  pages={207-13}
}
The aim of this study was to investigate the effects of neonatal administration of diethylstilbestrol (DES) on the induction of mammary carcinomas (MCs) and dysplasias (MDs) induced by 7,12-dimethylbenz[a]anthracene (DMBA) in female rats. Three different methods of continuous administration of DES (1 microg) were used: 0-14, 0-5 and 6-14 days after birth, and all rats were given DMBA (10 mg) at 50 days after birth. All rats administered DES showed persistent estrus and anovulatory ovaries. In… CONTINUE READING