Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease.

@article{Ferreira2008EffectsON,
  title={Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease.},
  author={Joaquim J. Ferreira and Lu{\'i}s Felipe Paes de Almeida and L Cunha and Marina Ticmeanu and M{\'a}rio Miguel Rosa and Cristina Janu{\'a}rio and C. M. Mitu and Miguel Coelho and Leonor Correia-Guedes and Ana S Morgadinho and Teresa Nunes and Lyndon Christopher Wright and Am{\'i}lcar Falc{\~a}o and Cristina Sampaio and Patr{\'i}cio Soares-da-Silva},
  journal={Clinical neuropharmacology},
  year={2008},
  volume={31 1},
  pages={2-18}
}
OBJECTIVE To investigate the effects of nebicapone, a new catechol-O-methyltransferase (COMT) inhibitor, on levodopa pharmacokinetics, COMT activity, and motor fluctuations in Parkinson disease in comparison to placebo and entacapone. METHODS Randomized, double-blind, placebo-controlled, 4-way crossover study consisting of 4 treatment periods (6-9 days duration each) in 19 patients (65.3 +/- 8.5 years) treated with carbidopa/levodopa 3 to 7 times per day. Nebicapone/entacapone/placebo and… CONTINUE READING
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Effect of single-doses of nebicapone (BIA 3-202) on the catechol-O-methyltransferase (COMT) activity in healthy subjects (abstract)

  • L Almeida, A Falcao, M Vaz-da-Silva
  • Mov Disord
  • 2006
1 Excerpt

Effect of single-doses of nebicapone (BIA 3-202) on the levodopa pharmacokinetics in healthy subjects

  • M Vaz-da-Silva, L Almeida, A Falcao
  • Mov Disord 2006;21:S637YS638
  • 2006

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