Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships.

@article{Kim1999EffectsON,
  title={Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships.},
  author={H Kim and B S Cheon and Y. H. Kim and S Y Kim and H. P. Kim},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 5},
  pages={
          759-65
        }
}
Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: Structure-activity relationship and action mechanism
TLDR
Of these flavonoids that were evaluated, 2′,3′,5,7-tet-rahydroxyflavone and 3′,4′, 5,7 -tetrahydroxflav one (luteolin) showed the strongest inhibition and may have a potential as new anti-inflammatory agents.
Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cells
TLDR
Molecular mechanism of flavonoids in modulating nitric oxide production and its signaling pathway were investigated using lipopolysaccharide (LPS)-activated RAW264.7 cells and there was a striking pattern related to structural feature in modulation of LPS-mediated signaling pathways.
Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism.
TLDR
2',4',7-trimethoxyflavone (TMF) was proved to be a phospholipase A(2) (PLA(2)) inhibitor and showed in vivo anti-inflammatory activity by topical application against mouse croton oil-induced ear edema assay, suggesting a potential for new anti- inflammatory agent.
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages.
TLDR
The present study supports the use of W. indica for the treatment of inflammatory diseases in traditional medicine by demonstrating significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide.
Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7).
TLDR
The results of this study suggest the anti-inflammatory properties of lutein demonstrated by the decrease in the expression of iNOS at the mRNA and protein levels in RAW 264.7 mouse macrophage cells.
Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation
TLDR
Results suggest that the suppressive effect of flavonoids on iNOS expression could account for the potent inhibitory effect of Dpm- and SNP-diffusates on NO production by activated macrophages.
The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells
TLDR
The results indicate that the inhibitory action of quercetin on NO production in LPS- and/or IFN-γ-stimulated macrophages might be due to abrogation of iNOS protein induction by impairment of a series of intracellular signal pathways.
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References

SHOWING 1-10 OF 21 REFERENCES
(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB
TLDR
The results suggest that EGCG decreases the activity and protein levels of iNOS by reducing the expression ofiNOS mRNA and the reduction could occur through prevention of the binding of nuclear factor-kappaB to the iN OS promoter, thereby inhibiting the induction of i NOS transcription.
In vitro Attenuation of Nitric Oxide Production in C6 Astrocyte Cell Culture by Various Dietary Compounds
  • K. Soliman, E. Mazzio
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1998
TLDR
A possible value for dietary compounds to inhibit the excessive production of NO is demonstrated, including milk thistle, silymarin, grapenol, and green tea, which reduce NO production at less than 300 ppm.
Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants
TLDR
It was found that isoflavones including daidzein and tectorigenin possessed the inhibitory activity on cyclooxygenase, although the potency of inhibition was far less than that of indomethacin.
Effects of isoflavonoids on mouse lymphocyte proliferationin vitro
TLDR
All isoflavones tested did not show the suppressive activity against lymphocyte proliferation induced by B-cell mitogen, lipopolysaccharide (LPS).
Protein kinase C and tyrosine kinase pathways regulate lipopolysaccharide‐induced nitric oxide synthase activity in RAW 264.7 murine macrophages
TLDR
The results suggest the involvement of protein kinase C, tyrosine kinase and ploy‐ADP ribosylation pathways in the regulation of the induction of nitric oxide synthase in RAW 264.7 macrophages by LPS and IFNγ.
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