Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages

@inproceedings{Mwimanzi2011EffectsON,
  title={Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages},
  author={Philip Mwimanzi and Zafrul Hasan and Ranya Hassan and Shinya Suzu and Masafumi Takiguchi and Takamasa Ueno},
  booktitle={Retrovirology},
  year={2011}
}
Although HIV can infect several cellular subsets, such as CD4+ T lymphocytes and macrophages, it remains unclear whether an HIV infection in macrophages supports cytotoxic T lymphocyte (CTL) escape. Here, we tested two naturally-arising mutations located in the well-conserved polyproline region of Nef for their effects on CTL recognition, Nef's… CONTINUE READING