Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.

@article{Ko2011EffectsON,
  title={Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.},
  author={Wen-Ya Ko and Kristin A Kaercher and Emanuela Giombini and Paolo Marcatili and Alain Froment and Muntasir Eltayeb Ibrahim and Godfrey Lema and Thomas Nyambo and Sabah Ahmed Omar and Charles O Wambebe and Alessia Ranciaro and Jibril Hirbo and Sarah A Tishkoff},
  journal={American journal of human genetics},
  year={2011},
  volume={88 6},
  pages={741-754}
}
Malaria has been a very strong selection pressure in recent human evolution, particularly in Africa. Of the one million deaths per year due to malaria, more than 90% are in sub-Saharan Africa, a region with high levels of genetic variation and population substructure. However, there have been few studies of nucleotide variation at genetic loci that are relevant to malaria susceptibility across geographically and genetically diverse ethnic groups in Africa. Invasion of erythrocytes by Plasmodium… CONTINUE READING
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