Effects of naproxen on connective tissue changes in the adjuvant arthritic rat.

@article{Ackerman1979EffectsON,
  title={Effects of naproxen on connective tissue changes in the adjuvant arthritic rat.},
  author={Neil Richard Ackerman and Wendell H. Rooks and L D Shott and Harry Genant and Patrick Maloney and Elizabeth Howard West},
  journal={Arthritis and rheumatism},
  year={1979},
  volume={22 12},
  pages={
          1365-74
        }
}
The Freund's adjuvant-injected rat shares a number of features with the arthritis patient, viz the presence of a proliferative synovitis, joint swelling, and cartilage and bone erosion. Naproxen, a prostaglandin synthetase inhibitor which is an effective antiinflammatory agent in laboratory animals and humans, was evaluated as an inhibitor of connective tissue destruction in this model by use of radiologic and histopathologic analyses. Sixteen days after rats were injected with Freund's… CONTINUE READING

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