Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study.

@article{Ray2007EffectsON,
  title={Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study.},
  author={Lara A Ray and Kent Hutchison},
  journal={Archives of general psychiatry},
  year={2007},
  volume={64 9},
  pages={1069-77}
}
CONTEXT Clinical trials have suggested a modest effect of naltrexone as a pharmacotherapy for alcoholism, and a recent study has suggested that the effects may be moderated by variations in the mu-opioid receptor gene (OPRM1). However, the mechanism by which naltrexone may be differentially effective as a function of the OPRM1 genotype is unclear. OBJECTIVES (1) To replicate and expand on the association between the A118G single nucleotide polymorphism(SNP) of the OPRM1 gene and alcohol… CONTINUE READING
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Association be(REPRINTED) ARCH GEN PSYCHIATRY/ VOL 64 (NO

  • CA Hernandez-Avila, G Wand, X Luo, J Gelernter, HR. Kranzler
  • SEP 2007 WWW.ARCHGENPSYCHIATRY.COM
  • 2007

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