Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat

  title={Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat},
  author={S. Castellani and A. Giannini and P. M. Adams},
The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 μg/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 μg… Expand
Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats
Phencyclidine and NANM appear to exert many of their effects on unconditioned behavior through common mechanisms, including interaction with sigma receptors, consistent with previous suggestions that a muopiate receptor system may modulate some effects of PCP. Expand
Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats
The use of the fixed interval schedule of brain self-stimulation to study drug interactions is novel, and demonstrates that the highly reinforcing aspects of brain stimulation, known to be influenced by dopamine, may also be modulated by the endogenous opiate system. Expand
Neuropharmacological profile of aqueous extract of Anaphe venata larva (Notondotidae) in rats.
Results showed that these anaphe-induced behavioural effects are mediated via cholinergic, GABAergic, opioidergic and dopaminergic receptor systems with strong muscarinic-cholinergic receptors involvement in ataxia-induced behaviour, and suggest that muscranic-Cholinergic like drugs may be of benefit in the management of patients that present with clinical condition of seasonal ataxIA. Expand
A simple procedure for assessing ataxia in rats Effects of phencyclidine
The results suggest that the "paw slip test" can serve as a simple, reliable, objective and valid measure of drug-induced ataxia. Expand
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice
It is suggested that PCP enhances the brain HA turnover in mice by stimulating, probably indireclty, endogenous opioid systems. Expand
Involvement of cholinergic-muscarinic receptor in Anaphe venata -induced stretching-ataxia behavioral effects in rats
Anaphe venata entomophagy has previously been implicated in the aetiopathogenesis of seasonal ataxia in humans and altered motor function in rodents. Thus, we investigated the effect of A. venataExpand
Synthesis and characterization of phencyclidine and his derivatives
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to theExpand
Brain levels of neuropeptides in human chronic methamphetamine users
Human data are consistent with the possibility that, at least in the human striatum, long-term methamphetamine exposure leads to an adaptive process that is distinct from that which increases neuropeptide levels after acute methamphetamine exposure. Expand
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
A pharmacological model, which produces no sensory or motor loss was used to study how autotomy is related to pain, and showed that a total analgesia was produced in both phasic and tonic pain tests, in animals that exhibited autotomy. Expand
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.
: The authors studied 40 white men with acute phencyclidine (PCP) intoxication. On a random basis, 10 were treated with ascorbic acid, 10 with placebo, 10 with haloperidol, and 10 with a combinationExpand


Potentiation of apomorphine and D-amphetamine effects by naloxone.
The results are compatible with the suggestion that naloxone may potentiate both apomorphine and d-amphetamine by inhibiting an opiate receptor mechanism which normally interacts with catecholamine neuronal action. Expand
Phencyclidine-induced rotational behavior in rats with nigrostriatal lesions and its modulation by dopaminergic and cholinergic agents
PCP may induce rotational behavior by potentiating dopaminergic transmission, by blocking cholinergic activity, or both; both of these effects have been demonstrated to be important in the generation of circling behavior in rats with nigrostriatal lesions. Expand
Interaction between phencyclidine (PCP) and Gaba-ergic drugs: Clinical implications
It seems that (-) baclofen may prove to be useful in the management of PCP intoxication, as the development of surgical anesthesia manifested as the loss of a) righting reflex, b) pain sensation and c) corneal reflex. Expand
Effects of dopaminergic drugs on phencyclidine-induced behavior in the rat
The findings support suggested involvement of dopamine in phencyclidine-induced behavior and indicate the value of concurrent assessment of different phen cyclidine- induced behavior for evaluating neurotransmitter effects. Expand
Acute and chronic phencyclidine effects on locomotor activity, stereotypy and ataxia in rats.
The chronic behavioral changes demonstrated in this study may provide a model of PCP-induced psychological and cognitive changes seen following chronic usage in man. Expand
Phencyclidine-like discriminative effects of opioids in the rat.
  • S. Holtzman
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1980
Results provide further evidence that PCP and certain opioids share a common component of action that is probably mediated by neuronal substrates not usually associated with the activity of opioids. Expand
Behavioral activating effects of opiates and opioid peptides.
The similarity in the naloxone-reversible responses induced by opiates and certain opioid peptides suggests that the same underlying mechanisms may subserve their behavioral effects. Expand
Behavioral activating effects of opiates and opioid peptides.
The similarity in the naloxone-reversible responses induced by opiates and certain opioid peptides suggests that the same underlying mechanisms may subserve their behavioral effects. Expand
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
It has been shown that buprenorphine is a partial agonist of the mu type which both suppressed and precipitated abstinence in the morphine-dependent dog while morphine and propoxyphene are stronger agonists. Expand
Naloxone alters locomotion and interaction with environmental stimuli.
The results indicate that lower doses of naloxone may enhance interaction with environmental stimuli while the predominant effect of higher doses is a general suppression in behavioral activity. Expand