Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat

@article{Castellani2004EffectsON,
  title={Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat},
  author={Sam Castellani and A. James. Giannini and Perrie M. Adams},
  journal={Psychopharmacology},
  year={2004},
  volume={78},
  pages={76-80}
}
The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 μg/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 μg… 
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Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats
TLDR
Phencyclidine and NANM appear to exert many of their effects on unconditioned behavior through common mechanisms, including interaction with sigma receptors, consistent with previous suggestions that a muopiate receptor system may modulate some effects of PCP.
Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats
TLDR
The use of the fixed interval schedule of brain self-stimulation to study drug interactions is novel, and demonstrates that the highly reinforcing aspects of brain stimulation, known to be influenced by dopamine, may also be modulated by the endogenous opiate system.
Neuropharmacological profile of aqueous extract of Anaphe venata larva (Notondotidae) in rats.
TLDR
Results showed that these anaphe-induced behavioural effects are mediated via cholinergic, GABAergic, opioidergic and dopaminergic receptor systems with strong muscarinic-cholinergic receptors involvement in ataxia-induced behaviour, and suggest that muscranic-Cholinergic like drugs may be of benefit in the management of patients that present with clinical condition of seasonal ataxIA.
A simple procedure for assessing ataxia in rats Effects of phencyclidine
Involvement of cholinergic-muscarinic receptor in Anaphe venata -induced stretching-ataxia behavioral effects in rats
TLDR
The results showed that the A. venata PBS extract induced significant stretching and ataxia behavioural effects dose-dependently when compared to vehicle-treated rats, probably mediated via the activation of cholinergic-muscarinic receptor systems.
Synthesis and characterization of phencyclidine and his derivatives
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the…
Brain levels of neuropeptides in human chronic methamphetamine users
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
TLDR
A pharmacological model, which produces no sensory or motor loss was used to study how autotomy is related to pain, and showed that a total analgesia was produced in both phasic and tonic pain tests, in animals that exhibited autotomy.
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice
TLDR
It is suggested that PCP enhances the brain HA turnover in mice by stimulating, probably indireclty, endogenous opioid systems.

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