Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat

@article{Castellani2004EffectsON,
  title={Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat},
  author={S. Castellani and A. Giannini and P. M. Adams},
  journal={Psychopharmacology},
  year={2004},
  volume={78},
  pages={76-80}
}
The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 μg/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 μg… Expand
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