Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors.

@article{Palmer2003EffectsON,
  title={Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors.},
  author={Robert W. H. Palmer and Robert Jason Weiss and Randall M. Zusman and Ann E Haig and Susan K Flavin and Brian Macdonald},
  journal={American journal of hypertension},
  year={2003},
  volume={16 2},
  pages={135-9}
}
Nonsteroidal anti-inflammatory drugs interfere with certain antihypertensive therapies. In a double-blind study, 385 hypertensive patients stabilized on an angiotensin converting enzyme inhibitor were treated with nabumetone, celecoxib, ibuprofen, or placebo for 4 weeks. Ibuprofen caused significantly greater increases in systolic (P < .001) and diastolic (P < .01) blood pressures (BPs) compared to placebo, but not nabumetone or celecoxib. The proportion of patients with systolic BP increases… CONTINUE READING

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