Effects of myostatin deletion in aging mice.

@article{Morissette2009EffectsOM,
  title={Effects of myostatin deletion in aging mice.},
  author={Michael R. Morissette and Janelle C. Stricker and Michael A Rosenberg and Cattleya Buranasombati and Emily B Levitan and Murray A. Mittleman and Anthony Rosenzweig},
  journal={Aging cell},
  year={2009},
  volume={8 5},
  pages={
          573-83
        }
}
Inhibitors of myostatin, a negative regulator of skeletal muscle mass, are being developed to mitigate aging-related muscle loss. Knock-out (KO) mouse studies suggest myostatin also affects adiposity, glucose handling and cardiac growth. However, the cardiac consequences of inhibiting myostatin remain unclear. Myostatin inhibition can potentiate cardiac growth in specific settings (Morissette et al., 2006), a concern because of cardiac hypertrophy is associated with adverse clinical outcomes… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Similar Papers

Loading similar papers…