Effects of myocardial transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor for the improvement of heart function and angiogenesis after myocardial infarction.

@article{Yang2007EffectsOM,
  title={Effects of myocardial transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor for the improvement of heart function and angiogenesis after myocardial infarction.},
  author={Jinfu Yang and Wenwu Zhou and Wei Zheng and Yanlin Ma and Ling Lin and Tao Tang and Jianxin Liu and Jiefeng Yu and Xinmin Zhou and Jianguo Hu},
  journal={Cardiology},
  year={2007},
  volume={107 1},
  pages={17-29}
}
OBJECTIVE To establish the transfection method of vascular endothelial growth factor (VEGF) gene into mesenchymal stem cells (MSCs), to investigate the effect of this gene-transfected MSCs for heart function restoration and angiogenesis after myocardial infarction, and to compare the therapeutic differences among cell therapy, gene therapy, and combined therapy. METHODS Ischemic heart models were constructed in inbred Wistar rats by ligation of the left anterior descending coronary artery… CONTINUE READING

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