Corpus ID: 31621335

Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial.

@article{Ciotta2011EffectsOM,
  title={Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial.},
  author={L. Ciotta and M. Stracquadanio and I. Pagano and A. Carbonaro and M. Palumbo and F. Gulino},
  journal={European review for medical and pharmacological sciences},
  year={2011},
  volume={15 5},
  pages={
          509-14
        }
}
BACKGROUND Polycystic ovary syndrome is the most common cause of chronic anovulation infertility in women in fertile period, and it's characterized by an increased production of androgens and estrogens. The administration of myo-inositol, a B complex vitamin, was associated with a decreased of serum testosterone and simultaneously, due to its ability to increase insulin sensitivity, women who received myo-inositol showed a great improvement of the ovulary function. Besides, the supplementation… Expand
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TLDR
Myo-Inositol and melatonin proved to be efficient predictors for positive IVF outcomes, correlating with high oocyte quality, and routinely MI and M supplementation in the IVF protocols was integrated. Expand
Myo-Inositol’s Role in Assisted Reproductive Technology: Evidence for Improving the Quality of Oocytes and Embryos in Patients With Polycystic Ovary Syndrome
TLDR
There is a lack of statistically significant evidence to support the use of MI in enhancing the quality of oocyte and/or embryo in PCOS; however, many of the reviewed studies have shown a trend toward the improvement of embryo quality in women with PCOS after MI supplementation. Expand
The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial
TLDR
The present study findings suggest that myo-Inositol alters the gene expression in granulosa cells and improves oocyte and embryo quality among PCOS patients undergoing ART. Expand
Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials
TLDR
During IVF, MI is effective in both PCOS and non-PCOS women in saving gonadotropins, but reduces efficiently SL only in PCOS women. Expand
Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial
TLDR
This study shows that MYO should be considered in the treatment of infertile PCOS patients, as MYO administration increases clinical pregnancy rates, lowers total rFSH dose and the duration of the ovulation induction. Expand
Inositol Treatment and ART Outcomes in Women with PCOS
  • D. Garg, R. Tal
  • Medicine
  • International journal of endocrinology
  • 2016
TLDR
Current knowledge on ovarian stimulation and ART outcomes following inositol treatment in women with PCOS undergoing in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) is summarized. Expand
The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial
TLDR
The use of Myo-inositol is efficient enough to change sperm parameters to increase the chance of fertility and the therapeutic effect of this method was confirmed on induction of pregnancy in 18% of the treated patients. Expand
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TLDR
Inositols, which act as insulin sensitizers, have the potential to alter folliculogenesis and the functional ovarian reserve, with subsequent benefits to reproductive outcomes following IVF/ICSI treatment, but Published literature is unable to provide definitive evidence of its efficacy. Expand
Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies
TLDR
Myo-inositol is effective in normalizing ovarian function, improving oocyte and embryo quality in PCOS, however further evaluations by large multicentre randomized controlled trials are needed to assess the clinical pregnancy and live birth rates in ART. Expand
Pretreatment with myo-inositol in patients undergoing gonadotropins multiple follicular stimulation for IVF
TLDR
A positive role of myo-inositol in insulin-resistant women with PCOS could depend on defects in the insulin IPGmediated signaling pathway, that seems to be primarily implicated in the pathogenesis of insulin resistance in Myo Inositol. Expand
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References

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TLDR
Myo-inositol is a simple and safe treatment that is capable of restoring spontaneous ovarian activity and consequently fertility in most patients with PCOS, and did not cause multiple pregnancy. Expand
Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.
TLDR
Treatment of PCOS patients with Myo-inositol provided a decreasing of circulating insulin and serum total testosterone as well as an improvement in metabolic factors. Expand
Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.
TLDR
Data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function and there was an inverse relationship between body mass and treatment efficacy. Expand
Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality.
TLDR
It is proposed that higher concentrations of MI and E(2) in human FF appear to play a role in follicular maturity and provide a marker of good quality oocytes. Expand
Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.
TLDR
Treatment with myo-inositol and folic acid, but not folic Acid alone, reduces germinal vesicles and degenerated oocytes at ovum pick-up without compromising total number of retrieved oocytes in polycystic ovary syndrome patients. Expand
Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome
TLDR
It is hypothesized that the administration of d-chiro-inositol would replenish stores of the mediator and improve insulin sensitivity in 44 obese women with the polycystic ovary syndrome. Expand
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TLDR
It is concluded that, in lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities ( increased blood pressure and hypertriglyceridemia) of syndrome X. Expand
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TLDR
UCl(DCI) is inversely correlated with insulin sensitivity in women and is a strong independent predictor of insulin resistance in multivariate models, consistent with a defect in tissue availability or utilization of DCI in PCOS that may contribute to the insulin resistance of the syndrome. Expand
Insulin and hyperandrogenism in women with polycystic ovary syndrome
TLDR
New concepts and findings regarding insulin actions in PCOS women and how it is related to hyperandrogenemia are discussed. Expand
Effects of myo-inositol on the in-vitro maturation and subsequent development of mouse oocytes.
TLDR
It is suggested that MI may affect meiotic progression of mouse GV oocytes possibly by enhancing the intracellular Ca(2+) oscillations and Supplementation of MI in culture medium may be useful for human oocyte maturation. Expand
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