Effects of mutations in ribosomal protein L16 on susceptibility and accumulation of evernimicin.

@article{McNicholas2001EffectsOM,
  title={Effects of mutations in ribosomal protein L16 on susceptibility and accumulation of evernimicin.},
  author={Paul M. McNicholas and Paul A. Mann and David J Najarian and Lynn Miesel and Roberta S Hare and Todd A. Black},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 1},
  pages={79-83}
}
Chemical mutagenesis of Staphylococcus aureus RN450 generated two strains that displayed a stable reduction (30- to 60-fold) in susceptibility to evernimicin. Cell-free translation reactions demonstrated that the resistance determinant was located in the ribosomal fraction. Compared to ribosomes isolated from a wild-type strain, ribosomes from the mutant strains displayed an 8- to 10-fold reduction in affinity for [(14)C]evernimicin. In contrast, the mutants displayed no alteration in either… CONTINUE READING

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