Effects of muscarinic acetylcholine receptor activation on membrane currents and intracellular messengers in medium spiny neurones of the rat striatum.

@article{Lin2004EffectsOM,
  title={Effects of muscarinic acetylcholine receptor activation on membrane currents and intracellular messengers in medium spiny neurones of the rat striatum.},
  author={John Yi-Chung Lin and Kenny K. H. Chung and D C J Pinheiro De Castro and Gregory D Funk and Janusz Lipski},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 5},
  pages={1219-30}
}
Acetylcholine, acting through muscarinic receptors, modulates the excitability of striatal medium spiny neurones. However, the underlying membrane conductances and intracellular signalling pathways have not been fully determined. Our aim was to characterize excitatory effects mediated by M1 muscarinic acetylcholine receptors in these neurones using whole-cell patch-clamp recordings in brain slices of postnatal rats. Under voltage-clamp, muscarine evoked an inward current associated with an… CONTINUE READING