Effects of multiple deletions of murein hydrolases on viability, septum cleavage, and sensitivity to large toxic molecules in Escherichia coli.

@article{Heidrich2002EffectsOM,
  title={Effects of multiple deletions of murein hydrolases on viability, septum cleavage, and sensitivity to large toxic molecules in Escherichia coli.},
  author={Christoph Heidrich and Astrid Ursinus and J{\"u}rgen Berger and Heinz J. Schwarz and J. - V. H{\"o}ltje},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 22},
  pages={
          6093-9
        }
}
The multiplicity of murein hydrolases found in most bacteria presents an obstacle to demonstrating the necessity of these potentially autolytic enzymes. Therefore, Escherichia coli mutants with deletions in multiple murein hydrolases, including lytic transglycosylases, amidases, and DD-endopeptidases, were constructed. Even a mutant from which seven different hydrolases were deleted was viable and grew at a normal rate. However, penicillin-induced lysis was retarded. Most of the mutants were… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 84 CITATIONS, ESTIMATED 59% COVERAGE

143 Citations

051015'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 143 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…