Effects of motexafin gadolinium on DNA damage and X-ray-induced DNA damage repair, as assessed by the Comet assay.

@article{Donnelly2005EffectsOM,
  title={Effects of motexafin gadolinium on DNA damage and X-ray-induced DNA damage repair, as assessed by the Comet assay.},
  author={Erling T. Donnelly and Yanfeng Liu and Tracy K Paul and Sara Rockwell},
  journal={International journal of radiation oncology, biology, physics},
  year={2005},
  volume={62 4},
  pages={
          1176-86
        }
}
PURPOSE To investigate the effects of motexafin gadolinium (MGd) on the levels of reactive oxygen species (ROS), glutathione (GSH), and DNA damage in EMT6 mouse mammary carcinoma cells. The ability of MGd to alter radiosensitivity and to inhibit DNA damage repair after X-ray irradiation was also evaluated. METHODS AND MATERIALS Reactive oxygen species and GSH levels were assessed by 2,7-dichlorofluorescein fluorescence flow cytometry and the Tietze method, respectively. Cellular… Expand
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