Effects of morphine on release of acetylcholine in the rat striatum: an in vivo microdialysis study

@article{Taguchi1993EffectsOM,
  title={Effects of morphine on release of acetylcholine in the rat striatum: an in vivo microdialysis study},
  author={Kyoji Taguchi and Yukihiko Hagiwara and Yukiko Suzuki and Takao Kubo},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1993},
  volume={347},
  pages={9-13}
}
We examined the effect of morphine on the release of acetylcholine (ACh) in the striatum of freely moving rats using the in vivo microdialysis method. The basal level of ACh was 3.01 ± 0.51 pmol/30 μl/15 min in the presence of neostigmine (10 μM). Tetrodotoxin (1 μM), a selective blocker of voltage-dependent Na+ channels, rapidly decreased the release of ACh in the striatal perfusates. Morphine at a dose of 10 mg/kg (i.p.) caused a reduction of ACh release in the striatum at 90–150 min. However… CONTINUE READING