Effects of morphine and naloxone on separation distress and approach attachment: evidence for opiate mediation of social affect.

@article{Herman1978EffectsOM,
  title={Effects of morphine and naloxone on separation distress and approach attachment: evidence for opiate mediation of social affect.},
  author={Barbara H Herman and Jaak Panksepp},
  journal={Pharmacology, biochemistry, and behavior},
  year={1978},
  volume={9 2},
  pages={213-20}
}
In order to determine the relationship between endorphins and social attachment, the effects of morphine (an opiate agonist) and naloxone (an opiate antagonist) on various indices of attachment in guinea pigs were studied. In infants, crying or separation-induced distress vocalizations were significantly decreased by single injections of low morphine doses (0.25, .050 and 0.75 mg/kg) in a dose-dependent manner. Naloxone (1mg/kg1 reliably increased separation distress vocalizations in both… CONTINUE READING
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