Effects of morphine and meperidine on action potential production in frog's skeletal muscle fibers.

@article{Frank1975EffectsOM,
  title={Effects of morphine and meperidine on action potential production in frog's skeletal muscle fibers.},
  author={G. B. Frank and H. Buttar},
  journal={Canadian journal of physiology and pharmacology},
  year={1975},
  volume={53 1},
  pages={
          92-6
        }
}
  • G. B. Frank, H. Buttar
  • Published 1975
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
Morphine (3.3 times 10-minus 4 M) and meperidine (8.8 times 10-minus 5 M) inhibited action potential production in frog's skeletal muscle fibers. Over these concentration ranges, neither the resting membrane potentials nor the resting membrane electric properties of the fibers appeared to be modified. Both drugs depressed excitability and the rising phase of the action potential by inhibiting the specific increase in sodium conductance which normally follows an adequate stimulus. Both drugs… Expand
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  • Canadian journal of physiology and pharmacology
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