Effects of morphine and U-50,488H on neurochemical activity of the hypothalamic noradrenergic neurons and pituitary-adrenal response.

Abstract

We examined the ability of morphine and U-50,488 H administered acutely to the rat to modify the hypothalamic noradrenaline (NA) content and turnover as well as corticosterone release. Hypothalamic NA and its metabolite 3-methoxy-4-hydroxy-phenylethylen glycol (MHPG) were determined by high-performance liquid chromatography (HPLC). Plasma corticosterone was… (More)

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