Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities

@article{Irazusta2003EffectsOM,
  title={Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities},
  author={Jon Irazusta and Gorka Larrinaga and Naiara Agirregoitia and Adolfo Leyva de Varona and Luis Casis},
  journal={Regulatory Peptides},
  year={2003},
  volume={110},
  pages={225-230}
}
The endogenous opioid neuropeptide system seems to be involved in the neural processes which underlie drug addiction. Several studies have reported that the administration of morphine induces changes in the levels and/or activity of endogenous opioid peptides (enkephalin, dynorphin) and their precursors in specific brain regions of the adult CNS. The aim of this work was to study the effects of chronic morphine exposure and its withdrawal on certain aminopeptidases capable of degrading opioid… CONTINUE READING

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