Effects of monoamine releasers with varying selectivity for releasing dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys

@article{Banks2011EffectsOM,
  title={Effects of monoamine releasers with varying selectivity for releasing dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys},
  author={Matthew L. Banks and Bruce E. Blough and S Stevens Negus},
  journal={Behavioural Pharmacology},
  year={2011},
  volume={22},
  pages={824–836}
}
Monoamine releasers constitute one class of candidate medications for the treatment of cocaine abuse, and concurrent cocaine-versus-food choice procedures are potentially valuable as experimental tools to evaluate the efficacy and safety of candidate medications. This study assessed the choice between cocaine and food by rhesus monkeys during treatment with five monoamine releasers that varied in selectivity to promote the release of dopamine and norepinephrine versus serotonin (5HT) [m… 
Abuse-related effects of dual dopamine/serotonin releasers with varying potency to release norepinephrine in male rats and rhesus monkeys.
TLDR
Comparing effects of four novel DA/5HT releasers that varied >800-fold in their selectivities suggests that potency to release NE has minimal influence on abuse liability of dualDA/5 HT releasers, and reducing relative potency torelease NE versus DA/ 5HT does not improve anticocaine efficacy.
Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys
TLDR
Efficacy of chronic PDM to reduce cocaine self-administration by rhesus monkeys is determined using a novel procedure that featured both daily assessments of cocaine vs food choice and medication efficacy to reallocate behavior away from cocaine choice and toward choice of an alternative reinforcer.
Cocaine-like discriminative stimulus effects of “norepinephrine-preferring” monoamine releasers: time course and interaction studies in rhesus monkeys
TLDR
Data suggest that greater potency for NE relative to dopamine release does not interfere with the ability of a monoamine releaser to produce cocaine-like discriminative effects but that increased serotonin release may have an inhibitory effect.
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
Evaluation of the Reinforcing Strength of Phendimetrazine Using a Progressive-Ratio Schedule of Reinforcement in Rhesus Monkeys
TLDR
The reinforcing strength of cocaine and phendimetrazine is compared, a prodrug for the amphetamine-like monoamine releaser phenmetrazine, a drug that has been shown to decrease cocaine use in some studies, and these results support PDM as Schedule III and highlight the importance of schedule parameters when comparing reinforce strength of drugs using a PR schedule of reinforcement.
Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure
TLDR
Lisdexamfetamine has a slower onset and longer duration of action than amphetamine but retains amphetamine’s efficacy to reduce the choice of cocaine in rhesus monkeys, and these results support further consideration of lisdexemfetamine as an agonist-based medication candidate for cocaine addiction.
Effects of 14-day treatment with the schedule III anorectic phendimetrazine on choice between cocaine and food in rhesus monkeys.
Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats
TLDR
The study of the effects of phenmetrazine on cocaine self-administration to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse, provides further support for the use of monoamine releasers as agonist medications for cocaine abuse.
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