Effects of monoamine releasers with varying selectivity for releasing dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys

  title={Effects of monoamine releasers with varying selectivity for releasing dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys},
  author={Matthew L. Banks and Bruce E. Blough and S Stevens Negus},
  journal={Behavioural Pharmacology},
Monoamine releasers constitute one class of candidate medications for the treatment of cocaine abuse, and concurrent cocaine-versus-food choice procedures are potentially valuable as experimental tools to evaluate the efficacy and safety of candidate medications. This study assessed the choice between cocaine and food by rhesus monkeys during treatment with five monoamine releasers that varied in selectivity to promote the release of dopamine and norepinephrine versus serotonin (5HT) [m… 
Abuse-related effects of dual dopamine/serotonin releasers with varying potency to release norepinephrine in male rats and rhesus monkeys.
Comparing effects of four novel DA/5HT releasers that varied >800-fold in their selectivities suggests that potency to release NE has minimal influence on abuse liability of dualDA/5 HT releasers, and reducing relative potency torelease NE versus DA/ 5HT does not improve anticocaine efficacy.
Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys
Efficacy of chronic PDM to reduce cocaine self-administration by rhesus monkeys is determined using a novel procedure that featured both daily assessments of cocaine vs food choice and medication efficacy to reallocate behavior away from cocaine choice and toward choice of an alternative reinforcer.
Cocaine-like discriminative stimulus effects of “norepinephrine-preferring” monoamine releasers: time course and interaction studies in rhesus monkeys
Data suggest that greater potency for NE relative to dopamine release does not interfere with the ability of a monoamine releaser to produce cocaine-like discriminative effects but that increased serotonin release may have an inhibitory effect.
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
Evaluation of the Reinforcing Strength of Phendimetrazine Using a Progressive-Ratio Schedule of Reinforcement in Rhesus Monkeys
The reinforcing strength of cocaine and phendimetrazine is compared, a prodrug for the amphetamine-like monoamine releaser phenmetrazine, a drug that has been shown to decrease cocaine use in some studies, and these results support PDM as Schedule III and highlight the importance of schedule parameters when comparing reinforce strength of drugs using a PR schedule of reinforcement.
Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure
Lisdexamfetamine has a slower onset and longer duration of action than amphetamine but retains amphetamine’s efficacy to reduce the choice of cocaine in rhesus monkeys, and these results support further consideration of lisdexemfetamine as an agonist-based medication candidate for cocaine addiction.
Effects of 14-day treatment with the schedule III anorectic phendimetrazine on choice between cocaine and food in rhesus monkeys.
Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats
The study of the effects of phenmetrazine on cocaine self-administration to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse, provides further support for the use of monoamine releasers as agonist medications for cocaine abuse.


Selective Suppression of Cocaine- versus Food-Maintained Responding by Monoamine Releasers in Rhesus Monkeys: Benzylpiperazine, (+)Phenmetrazine, and 4-Benzylpiperidine
Findings support the potential utility of dopamine-selective releasers as candidate treatments for cocaine dependence and examine the effects of the releasers benzylpiperazine, (+)phenmetrazine, and 4-benzylpipersidine, which have 20- to 48-fold selectivity in vitro for releasing dopamine versus serotonin.
Monoamine Releasers with Varying Selectivity for Dopamine/Norepinephrine versus Serotonin Release as Candidate “Agonist” Medications for Cocaine Dependence: Studies in Assays of Cocaine Discrimination and Cocaine Self-Administration in Rhesus Monkeys
The results are consistent with the conclusion that dopamine/norepinephrine-selective releasers retain cocaine-like abuse-related effects but may also be capable of producing relatively selective reductions in the reinforcing effects of cocaine.
Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys
These results are consistent with the hypothesis that chronic treatment with d-amphetamine decreases cocaine self-administration in rhesus monkeys, possibly by attenuating the reinforcing effects of cocaine.
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
It is shown that chronic administration of EKC and U50,588 produce a dose-dependent, kappa receptor-mediated and often sustained decrease in cocaine self-administration, which may complicate their use as treatments for cocaine dependence.
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys
It is suggested that continuous treatment with U50,488 produces a kappa receptor-mediated increase in the relative reinforcing effects of cocaine in comparison with food.
Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys
Data suggest that prolonged d-amphetamine treatment may be necessary to produce a sustained reduction in the reinforcing effects of cocaine under conditions in which access to cocaine was suspended during d- methamphetamine treatment.
Rapid Assessment of Choice between Cocaine and Food in Rhesus Monkeys: Effects of Environmental Manipulations and Treatment with d-Amphetamine and Flupenthixol
  • S. Negus
  • Biology, Psychology
  • 2003
The results suggest that this choice procedure may be useful for the evaluation of both environmental determinants of cocaine use and candidate pharmacotherapies for the treatment of cocaine abuse.
Acute and chronic effects of flupenthixol on the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys.
Neither acute nor chronic treatment with a low dose of flupenthixol significantly altered the discriminative stimulus or reinforcing effects of cocaine.