Effects of monensin on posttranslational processing of myelin proteins.

@article{Townsend1983EffectsOM,
  title={Effects of monensin on posttranslational processing of myelin proteins.},
  author={Laurace E. Townsend and Joyce A Benjamins},
  journal={Journal of neurochemistry},
  year={1983},
  volume={40 5},
  pages={1333-9}
}
Rat brain slices were incubated with [3H]palmitic acid and [14C]glycine to label the lipid and protein moieties, respectively, of myelin proteolipid protein (PLP). The effects of monensin on posttranslational processing of proteins were examined by measuring the appearance of [14C]glycine- and [3H]palmitate-labeled proteins in myelin and myelin-like fractions. At 0.01 and 0.10 microM, monensin did not appreciably affect total lipid or protein synthesis; higher concentrations caused increased… CONTINUE READING