Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture.

@article{Keller2008EffectsOM,
  title={Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture.},
  author={Kate E. Keller and John M. B. Bradley and Mary Jane Kelley and Ted S. Acott},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 6},
  pages={2495-505}
}
PURPOSE Glycosaminoglycans (GAGs) have been implicated in the regulation of outflow resistance of aqueous humor flow through the trabecular meshwork (TM). Their role was further investigated by assessment of the effects of chlorate, an inhibitor of sulfation, and beta-xyloside, which provides a competitive nucleation point for addition of disaccharide units, in anterior segment perfusion culture. METHODS Outflow facility was measured in perfused porcine and human anterior organ cultures… CONTINUE READING

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