Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy?

@article{Du2013EffectsOM,
  title={Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy?},
  author={Mei Fang Du and Mingyuan Wu and Dongxu Fu and Steve Ta-Shen Yang and Jinfeng Chen and KennethS. Wilson and Timothy J Lyons},
  journal={Diabetologia},
  year={2013},
  volume={56},
  pages={2318-2328}
}
Aims/hypothesisBlood–retina barrier leakage in diabetes results in extravasation of plasma lipoproteins. Intra-retinal modified LDLs have been implicated in diabetic retinopathy (DR), but their effects on retinal pigment epithelial (RPE) cells and the added effects of extravasated modified HDLs are unknown.MethodsIn human retinas from individuals with and without diabetes and DR, immunohistochemistry was used to detect ApoB, ApoA1 and endoplasmic reticulum (ER) stress markers. In cell culture… CONTINUE READING
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