Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.

@article{Volkow2009EffectsOM,
  title={Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.},
  author={Nora D. Volkow and Joanna S. Fowler and Jean Logan and David Alexoff and Wei Zhu and Frank Telang and Gene-Jack Wang and Millard Jayne and Jacob M. Hooker and Christopher Wong and Barbara Hubbard and Pauline Carter and Donald Warner and Payton King and Colleen Shea and Youwen Xu and Lisa Muench and Karen Apelskog-Torres},
  journal={JAMA},
  year={2009},
  volume={301 11},
  pages={
          1148-54
        }
}
CONTEXT Modafinil, a wake-promoting drug used to treat narcolepsy, is increasingly being used as a cognitive enhancer. Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise. OBJECTIVE To measure the acute effects of modafinil at doses used therapeutically (200 mg and 400 mg given orally) on extracellular dopamine and on dopamine transporters in the male human brain. DESIGN… CONTINUE READING

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