Effects of mitomycin C on infiltration of polymorphonuclear leukocytes after epithelial scrape injury in the mouse cornea.

@article{Escario2008EffectsOM,
  title={Effects of mitomycin C on infiltration of polymorphonuclear leukocytes after epithelial scrape injury in the mouse cornea.},
  author={Ana Cec{\'i}lia de Souza Le{\~a}o Escari{\~a}o and Takayuki Nagasaki and Jin Zhong Zhao and Richard Braunstein},
  journal={Arquivos brasileiros de oftalmologia},
  year={2008},
  volume={71 6},
  pages={822-6}
}
PURPOSE To determine whether mitomycin C (MMC) alters appearance and disappearance of polymorphonuclear leucocytes (PMN) in the cornea stroma, using an epithelial scrape injury in eye mouse model. METHODS Twenty-mice underwent mechanical epithelium debridement in the central cornea using 20% ethanol. After the scrape, the right eye received 0.02% MMC for one minute, while the left eye received physiological saline. The animals were sacrificed on days 1, 2, 5, and 14 after surgery, and corneal… CONTINUE READING