Effects of mitochondrial swelling and calcium on phosphate-activated glutaminase in pig renal mitochondria.

@article{Kvamme1991EffectsOM,
  title={Effects of mitochondrial swelling and calcium on phosphate-activated glutaminase in pig renal mitochondria.},
  author={Elling Kvamme and Bj\org Roberg and Ingeborg Aa. Torgner},
  journal={European journal of biochemistry},
  year={1991},
  volume={197 3},
  pages={675-80}
}
The effects of mitochondrial swelling and calcium have been used to study the possible function of the glutamine transporter in regulating glutamine hydrolysis. Salt-induced swelling of pig renal mitochondria and an iso-osmotic mixed salt solution and swelling caused by reducing the osmolarity of the incubation medium, are accompanied by activation of glutamine hydrolysis. Regulation of the glutaminase activity by salt-induced mitochondrial swelling is likely to have physiological importance… CONTINUE READING