Effects of minodronic acid and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys.

@article{Yamagami2013EffectsOM,
  title={Effects of minodronic acid and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys.},
  author={Yoshiki Yamagami and Tasuku Mashiba and Ken Iwata and Makoto Tanaka and Kazutoshi Toyota-shi Nozaki and Tetsuji Yamamoto},
  journal={Bone},
  year={2013},
  volume={54 1},
  pages={
          1-7
        }
}
Suppression of bone remodeling by bisphosphonates leads to accumulation of microdamage in bone. If this microdamage develops due to suppressed repair of remodeling only, more potent bisphosphonates should cause more damage. In this study, we evaluated the effects of reduced bone turnover produced by a potent bisphosphonate, minodronic acid, on microdamage accumulation, the degree of mineralization and mechanical properties of bone in ovariectomized cynomolgus monkeys, and compared these effects… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Minodronate for the treatment of osteoporosis

  • Therapeutics and clinical risk management
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Histological and micro Computed Tomography analysis of a femoral stress fracture associated with prolonged bisphosphonate use.

  • Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

Localization of Minodronate in Mouse Femora Through Isotope Microscopy.

  • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2010

Similar Papers

Loading similar papers…