Effects of mineralocorticoids, altered sodium intake, and adrenalectomy on urinary kallikrein in rats.

@article{Geller1972EffectsOM,
  title={Effects of mineralocorticoids, altered sodium intake, and adrenalectomy on urinary kallikrein in rats.},
  author={R G Geller and Harry S. Margolius and John J. Pisano and Harry R. Keiser},
  journal={Circulation research},
  year={1972},
  volume={31 6},
  pages={857-61}
}
The urinary excretion of kallikrein was examined in rats whose mineralocorticoid level was increased by the administration of deoxycorticosterone or a low-sodium diet and decreased by adrenalectomy. Administration of deoxycorticosterone by injection or by subcutaneous implantation of pellets resulted in a threefold increase in kallikrein excretion after 10-30 days (P<0.01) . Low-sodium intake produced a twofold increase in kallikrein excretion after 2 and 4 weeks (P<0 .01) . Urine volume and… CONTINUE READING

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