Effects of microinjections of neurotoxin AvTx8, isolated from the social wasp Agelaia vicina (Hymenoptera, Vespidae) venom, on GABAergic nigrotectal pathways

@article{Oliveira2005EffectsOM,
  title={Effects of microinjections of neurotoxin AvTx8, isolated from the social wasp Agelaia vicina (Hymenoptera, Vespidae) venom, on GABAergic nigrotectal pathways},
  author={Luciana de Oliveira and Alexandra Olimpio Siqueira Cunha and Marcia R. Mortari and Andr{\'e}a Baldocchi Pizzo and Antonio Miranda and Norberto Cysne Coimbra and Wagner Ferreira dos Santos},
  journal={Brain Research},
  year={2005},
  volume={1031},
  pages={74-81}
}
Several investigations have provided information that defensive behaviors evoked by stimulation of deep layers of the superior colliculus (dlSC) are subjected to inhibitory nigral modulation. This inhibition is made mainly through GABAergic neurons from substantia nigra, pars reticulata (SNpr), that sends outputs toward neural networks of the deep layers of the superior colliculus and dorsal periaqueductal gray matter involved with the organization of fear-like responses. In this work, we… 
Functional and ultrastructural neuroanatomy of interactive intratectal/tectonigral mesencephalic opioid inhibitory links and nigrotectal GABAergic pathways: Involvement of GABAA and μ1-opioid receptors in the modulation of panic-like reactions elicited by electrical stimulation of the dorsal midbrai
TLDR
Evidence is offered of a neuroanatomical basis of a pre-synaptic opioid inhibition of GABAergic nigrotectal neurons modulating fear in defensive behavior-related structures of the cranial mesencephalon through a major neural circuit.
Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)
TLDR
Findings suggest that A. vicina venom may affect neural substrates involved with catalepsy in the central nervous system, which is commonly experienced by patients with chronic use of many antiparkisonism and neuroleptic drugs.
Anticonvulsant and behavioural effects of the denatured venom of the social wasp Polybia occidentalis (Polistinae, Vespidae).
TLDR
The findings may indicate that the denatured venom has anticonvulsant activity with scarce propensity to cause neurological side-effects, and further studies are necessary to isolate the active compound and establish its mechanism of action.
Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive behavior and fear-induced analgesia
TLDR
These findings support the contention that serotonin and GABAergic neurons may act in concert in the modulation of defense reaction in the midbrain tectum, and indicate a direct neural pathway connecting the dorsal midbrain and monoaminergic nuclei of the descending pain inhibitory system.
Topographic and functional neuroanatomical study of GABAergic disinhibitory striatum–nigral inputs and inhibitory nigrocollicular pathways: Neural hodology recruiting the substantia nigra, pars reticulata, for the modulation of the neural activity in the inferior colliculus involved with panic-like
TLDR
It is suggested that the substantia nigra receives GABAergic inputs that modulate local and also inhibitory GABAergic outputs toward the IC, as well as between the neostriatum and SNpr.
Anticonvulsant effects of the wasp Polybia ignobilis venom on chemically induced seizures and action on GABA and glutamate receptors.
TLDR
The effects of direct exposure of rat brains to the crude and denatured venom of the Brazilian social wasp Polybia ignobilis are described and these interactions of venom components with GABA and glutamate receptors could be responsible for the anticonvulsant effects introducing the venom from P. ign mobilis as a potential pharmacological source of anticonVulsant drugs.
Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission
TLDR
The effects of the compound agelaiatoxin‐8 (AVTx8), isolated from Agelaia vicina venom, on γ‐aminobutyric acid (GABA) neurotransmission in rat brain synaptosomes are shown and it is suggested that AvTx8 modulates GABA neurotransmission and might provide a novel entry point for identifying a new class of GABA‐modulating neuroprotective drugs.
Interactions between opioid-peptides-containing pathways and GABAA-receptors-mediated systems modulate panic-like-induced behaviors elicited by electric and chemical stimulation of the inferior colliculus
TLDR
An interaction between endogenous opioid-peptides-containing connections and GABA(A)-receptor-mediated system with direct influence on the organization of the panic-like or fear-induced responses elaborated in the inferior colliculus during critical emotional states is suggested.
GABAA receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced antinociception
TLDR
It is suggested that dysfunction of the GABA-mediated neuronal system in the medial hypothalamus causes panic-like responses in laboratory animals, and that the elaborated escape behaviour organized in both dorsomedial and ventromedial hypothalamic nuclei are followed by significant innate-fear-induced antinociception.
The effects of the Brazilian antDinoponera quadriceps venom on chemically induced seizure models
TLDR
D. quadriceps venom caused both neuroprotective and neurotoxic effects in a PTZ-induced seizure model, and this effect was dependent on the route of administration used.
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