Effects of microRNA-30a on migration, invasion and prognosis of hepatocellular carcinoma.

@article{Liu2014EffectsOM,
  title={Effects of microRNA-30a on migration, invasion and prognosis of hepatocellular carcinoma.},
  author={Zhaoyang Liu and Kangsheng Tu and Qingguang Liu},
  journal={FEBS letters},
  year={2014},
  volume={588 17},
  pages={3089-97}
}
The role of microRNA-30a (miR-30a) deregulation in tumor progression and its downstream signaling pathways remain unknown. Here we confirmed significant downregulation of miR-30a in hepatocellular carcinoma (HCC) tissues and cell lines compared with non-tumor counterparts. MiR-30a downregulation was significantly associated with worse disease-free survival (DFS) of HCC patients. Gain- and loss-of-function studies revealed that downregulation of miR-30a facilitated tumor cell migration, invasion… CONTINUE READING