Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy

@article{Cutrona2017EffectsOM,
  title={Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy},
  author={Giovanna Cutrona and Serena Matis and Massimo Colombo and Carlotta Massucco and G Baio and Franscesca Valdora and Laura Emionite and Sonia Fabris and Anna Grazia Recchia and Massimo Gentile and Carlo Emanuele Neumaier and Daniele Reverberi and Rosanna Massara and Simona Boccardo and Luca Basso and Sandra Salvi and Francielle Rosa and Michele Cilli and Simona Zupo and Mauro Truini and Pierfrancesco Tassone and Mariaconsiglia Calabrese and Massimo Negrini and Antonino Neri and F. Morabito and Franco Fais and Massimo Ferrarini},
  journal={Leukemia},
  year={2017},
  volume={31},
  pages={1894-1904}
}
Chronic lymphocytic leukemia (CLL) clones are characterized by loss of a critical region in 13q14.3, (del(13)(q14)) involving the microRNA (miRNA) cluster miR-15a and miR-16-1. We have investigated the effects of replacement of miR-15a and miR-16-1. CLL cells transfected with these miRNA mimics exhibited a decrease in cell viability in vitro and impaired capacity for engraftment and growth in NOD/Shi-scid,γcnull (NSG) mice. No synergistic effects were observed when the two miRNA mimics were… CONTINUE READING