• Corpus ID: 39191167

Effects of metyrapone on the pharmacological activity, plasma levels and urinary excretion of the dopamine receptor agonist DK-118.

@article{Koons1985EffectsOM,
  title={Effects of metyrapone on the pharmacological activity, plasma levels and urinary excretion of the dopamine receptor agonist DK-118.},
  author={Jay C. Koons and John Paul Long and D. L. Koble and Joseph Gerard Cannon and Lawrence J. Fischer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={233 1},
  pages={
          51-7
        }
}
Possible metabolic activation of the dopamine receptor agonist DK-118 (5-hydroxy-6-methyl-N,N-di-n-propyl-2-aminotetralin) was investigated in cats. Metyrapone, an inhibitor of oxidative drug metabolism, was given to cats before DK-118 and the pharmacologic effects of the dopamine agonist were compared to those observed in nonpretreated animals. A sensitive high-performance liquid chromatography assay using electrochemical detection was developed to monitor urine and plasma concentrations of DK… 
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