Effects of metyrapone on hepatic cortisone-cortisol conversion in the rat.

@article{Thomson1998EffectsOM,
  title={Effects of metyrapone on hepatic cortisone-cortisol conversion in the rat.},
  author={Laura M Thomson and Peter W Raven and Kelvin E Smith and Joy P Hinson},
  journal={Endocrine research},
  year={1998},
  volume={24 3-4},
  pages={607-11}
}
In previous studies in human subjects metyrapone has been found to exert significant extra-adrenal effects, consistent with an effect on the 11-reductase activity of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). In the present study the effects of metyrapone on cortisone metabolism by rat liver microsomes were investigated. Aliquots of microsomal preparations were incubated with NADPH cofactor and different concentrations of cortisone for a range of time intervals up to 30 min. The products… CONTINUE READING