Effects of metronidazole on hepatic CYP3A4 activity.

  title={Effects of metronidazole on hepatic CYP3A4 activity.},
  author={Curtis E. Haas and David Charles Kaufman and Robert Dicenzo},
  volume={21 10},
STUDY OBJECTIVE To evaluate the effect of a short course of oral metronidazole, commonly used for bowel-preparation regimens, on hepatic cytochrome P450 (CYP) 3A4 activity, as measured by the [14C N-methyl]-erythromycin breath test (ERMBT) in healthy volunteers. DESIGN Prospective, nonrandomized, interventional study SETTING University-affiliated, community, teaching hospital. SUBJECTS Five healthy male volunteers. INTERVENTION Subjects underwent a baseline ERMBT in the morning before… CONTINUE READING
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