Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation.

@article{Dhein2011EffectsOM,
  title={Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation.},
  author={Stefan Dhein and Susanne Rothe and Andrea Busch and Diana Rojas Gomez and Andreas Boldt and Anja Reutemann and Thomas Seidel and Aida Salameh and Bettina Pfannmueller and Ardawan Julian Rastan and Martin Kostelka and Friedrich W. Mohr},
  journal={British journal of pharmacology},
  year={2011},
  volume={164 2b},
  pages={607-16}
}
BACKGROUND AND PURPOSE We investigated the influence of metoprolol on gap junction proteins connexin43 (Cx43) and connexin40 (Cx40) in atrial tissue from patients with/without atrial fibrillation (AF). EXPERIMENTAL APPROACH Left atrial tissue samples from 160 patients with AF or sinus rhythm (SR) with or without metoprolol (mean daily dose: 65.2 ± 9.1 mg·day⁻¹) were analysed for Cx43 and Cx40 by Western blot and immunohistology. Transverse and longitudinal conduction velocities were… CONTINUE READING

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We investigated the influence of metoprolol on gap junction proteins connexin43
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