Effects of metoprolol on myocardial β-adrenoceptors and Giα-proteins in patients with congestive heart failure

@article{Sigmund1996EffectsOM,
  title={Effects of metoprolol on myocardial β-adrenoceptors and Giα-proteins in patients with congestive heart failure},
  author={Martin Sigmund and H. Jakob and H. -J. Becker and Peter Hanrath and Carlos Schumacher and Thomas Eschenhagen and W. Schmitz and Hasso Scholz and Markus Steinfath},
  journal={European Journal of Clinical Pharmacology},
  year={1996},
  volume={51},
  pages={127-132}
}
Objective: In human heart failure downregulation of β-adrenoceptors and upregulation of Gi-protein α-subunits (Giα) results desensitization of the myocardial β-adrenergic signal transduction pathway and reduced positive inotropic effects of catecholamines. Metoprolol treatment has been shown to restore the reduced β-adrenoceptor density in dilated cardiomyopathy. The main objective of the present study was to investigate whether metoprolol also decreases the elevated inhibitory Giα levels in… CONTINUE READING

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Hjalmarson A (1994) b-Blocker treatment for chronic heart failure

  • EJ Eichhorn
  • The frog prince. Circulation
  • 1994
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