Effects of methylprednisolone on extracellular lactic acidosis and amino acids after severe compression injury of rat spinal cord.

Abstract

We evaluated in rats with severe spinal cord compression at T8-9 the influence of methylprednisolone (MP) on lactic acidosis and extracellular amino acids, which may cause secondary, perifocal injuries of the cord. MP (30 mg/kg) was given intravenously 30 min before compression and hourly thereafter (15 mg/kg). Other rats with compression, given saline… (More)

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