Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass.

@article{Rubens2005EffectsOM,
  title={Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass.},
  author={Fraser Douglas Rubens and Howard Nathan and Rosalind S. Labow and Kathryn S Williams and Denise Wozny and Jacob Karsh and Marc A Ruel and Thierry Mesana},
  journal={The Annals of thoracic surgery},
  year={2005},
  volume={79 2},
  pages={655-65}
}
BACKGROUND Cardiopulmonary bypass (CPB) induces derangements in physiology characterized by activation of blood pathways that may contribute to multiorgan dysfunction. This trial addresses the efficacy of a biocompatible surface alone and in combination with steroids in inhibiting these changes. METHODS In a factorial design, patients undergoing coronary artery bypass grafting were randomized (four groups; n = 17 per group) to CPB utilizing control circuits or a circuit prepared with a… CONTINUE READING
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