Effects of methylphenidate discontinuation on cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorder.

@article{Langleben2002EffectsOM,
  title={Effects of methylphenidate discontinuation on cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorder.},
  author={Daniel D. Langleben and Paul D. Acton and Glenn Austin and Igor Elman and Gary Krikorian and John R. Monterosso and Orith Portnoy and Hugh W Ridlehuber and H. William Strauss},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2002},
  volume={43 12},
  pages={1624-9}
}
UNLABELLED Methylphenidate (MPH) is an effective symptomatic treatment of attention deficit hyperactivity disorder (ADHD), but the mechanisms of its therapeutic action have not been fully elucidated. To address this issue, we assessed the effects of discontinuation of chronic MPH treatment on regional cerebral blood flow (rCBF) in ADHD patients. METHODS Twenty-two prepubescent boys with ADHD (age range, 8.2-11.5 y) and 7 healthy volunteers were studied with SPECT on and off MPH. Their rCBF… CONTINUE READING

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