Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of rat right ventricle and small mesenteric artery.

@article{AlSahli2001EffectsOM,
  title={Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of rat right ventricle and small mesenteric artery.},
  author={W Al-Sahli and Hasanabadi Ahmad and Farhad Kheradmand and Clara Connolly and James Docherty},
  journal={European journal of pharmacology},
  year={2001},
  volume={422 1-3},
  pages={
          169-74
        }
}
We have compared the effects of methylenedioxymethamphetamine (MDMA) and cocaine on contractions to noradrenaline in 1 Hz paced rat right ventricular strips, and in rat small mesenteric artery and aorta. Noradrenaline increased the force of contraction of 1 Hz paced ventricular strips with a pD(2) (-log EC(50)) of 5.64+/-0.07. Both cocaine (10 microM) and MDMA (10 microM) significantly increased the potency of noradrenaline to 6.31+/-0.11 and 6.42+/-0.13, respectively. However, in the presence… CONTINUE READING