Effects of methyl mercury on the microtubule system of mouse lymphocytes.

@article{Brown1988EffectsOM,
  title={Effects of methyl mercury on the microtubule system of mouse lymphocytes.},
  author={David L. Brown and Kenneth R. Reuhl and S Bormann and Jennifer E. Little},
  journal={Toxicology and applied pharmacology},
  year={1988},
  volume={94 1},
  pages={66-75}
}
The effects of in vivo and in vitro methyl mercury (MeHg) treatments on the microtubule system of murine splenic lymphocytes were examined by immunofluorescence microscopy. In vitro exposures to 1 to 10 microM MeHg resulted in time- and concentration-dependent microtubule disassembly. Lymphocytes isolated from mice receiving a single 10 mg/kg injection displayed microtubule damage when examined 2 and 5 days post-treatment. The capacity of in vivo and in vitro treated lymphocytes to respond to… CONTINUE READING

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