Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes.

@article{Seitz1998EffectsOM,
  title={Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes.},
  author={Michael Seitz and Marianne Zwicker and Pius Loetscher},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 11},
  pages={2032-8}
}
OBJECTIVE To examine the potential of methotrexate (MTX) to act as a differentiation-stimulating factor for monocytes, which could explain the antiinflammatory properties of this agent in the treatment of rheumatoid arthritis (RA). METHODS Fluorescence-activated cell sorter analysis was used to measure the changes in antigen expression (CD11b/c, CD16, CD64, CD14, CD68, and CD95) in response to MTX, 1,25-OH-cholecalciferol (1,25-OH-CCF), and granulocyte-macrophage colony-stimulating factor in… CONTINUE READING

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