Effects of methimazole on the elimination of irinotecan


To study the possible pharmacokinetic and pharmacodynamic interactions between irinotecan and methimazole. A patient treated for colorectal cancer with single agent irinotecan received methimazole co-medication for Graves’ disease. Irinotecan pharmacokinetics and side effects were followed during a total of four courses (two courses with and two courses… (More)
DOI: 10.1007/s00280-010-1414-x

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