Effects of methandienone on the performance and body composition of men undergoing athletic training.

@article{Hervey1981EffectsOM,
  title={Effects of methandienone on the performance and body composition of men undergoing athletic training.},
  author={G. R. Hervey and A. V. Knibbs and L. Burkinshaw and David B. Morgan and P. R. M. Jones and David R. Chettle and David Vartsky},
  journal={Clinical science},
  year={1981},
  volume={60 4},
  pages={
          457-61
        }
}
1. In a previous study of the effects of methandienone (Dianabol) on men undergoing athletic training, strength and performance increased, but not significantly more when the subjects were taking the drug than when they were taking placebo. The subjects did, however, gain more weight on the drug, with increases in total body potassium and muscle dimensions. It remained an open question whether the muscles had gained normal tissue or intracellular fluid. 2. In an attempt to distinguish between these possibilities the trial has been repeated, using as subjects seven male weight-lifters in regular training, and including measurements of total body nitrogen. [] Key Method As before, a dose of 100 mg of methandienone/day was given alternately with the placebo in a double-blind crossover experiment. The treatment periods lasted 6 weeks and were separated by an interval of 6 weeks. Body weight, potassium and nitrogen, muscle size, and leg performance and strength increased significantly during training on the drug, but not during the placebo period. 3. The finding of increased body nitrogen suggested that the weight gain was not only intracellular fluid. The…

Tables from this paper

The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
TLDR
Those given testosterone had greater increases than those given placebo in muscle size in their arms and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively.
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
TLDR
Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men.
SUPRAPHYSIOLOGIC DOSES OF TESTOSTERONE AND MUSCLE SIZE AND STRENGTH
TLDR
Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men.
Effect of testosterone administration and weight training on muscle architecture.
TLDR
The results of the present study suggest that the use of TE in conjunction with heavy resistance training is associated with muscle architecture changes that are commonly associated with high-force production.
Changes in neuromuscular performance and muscle fiber characteristics of elite power athletes self-administering androgenic and anabolic steroids.
TLDR
It is suggested that strength training in combination with administration of androgenic-anabolic steroids causes improvements in selected neuromuscular parameters that may be greater than those of caused by the strength training alone.
Effects of anabolic-androgenic steroids on muscular strength.
TLDR
No evidence was found to support enhanced muscle strength with steroid use in eight studies in untrained normal volunteers, and anabolic steroids may slightly enhance muscle strength in previously trained athletes.
Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception.
TLDR
The administration of testosterone enanthate in pharmacological doses for 6 months resulted in a modest reduction in fat mass and small increases in fat-free mass, muscle strength, and bone density, which do not support the use of androgens for enhancing athletic performance.
Effects of Androgenic-Anabolic Steroids in Athletes
TLDR
Although AAS administration may affect erythropoiesis and blood haemoglobin concentrations, no effect on endurance performance was observed and little data about the effects of AAS on metabolic responses during exercise training and recovery are available and, therefore, do not allow firm conclusions.
Anabolic-Androgenic Steroid Administration Causes Hypertrophy of Immobilized and Nonimmobilized Skeletal Muscle in a Sedentary Rabbit Model
TLDR
The results are contrary to previously accepted views that anabolic-androgenic steroid use leads to muscle hypertrophy only in conjunction with strength training and add to the growing evidence thatanabolic- androgenic steroids can produce significant skeletal musclehypertrophy in sedentary populations.
Bodybuilders' body composition: effect of nandrolone decanoate.
TLDR
The results show that the administration of 200 mg.wk(-1) of ND (intramuscularly) for 8 wk significantly increased body mass and FFM, whereas fat mass, bone mineral content, bone Mineral density, and the hydration of the FFM remained unaffected, indicating that the changes can be attributed to an increase of muscle mass.
...
...

References

SHOWING 1-10 OF 14 REFERENCES
Anabolic steroids in athelics: crossover double-blind trial on weightlifters.
TLDR
It is suggested that anabolic steroids are effective only when given combination with exercise and high-protein diet and no way of stopping it is suggested.
Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years
TLDR
Skinfold thicknesses at four sites – biceps, triceps, subscapular and supra-iliac – and total body density were measured on 209 males and 272 females aged from 16 to 72 years, finding it necessary to use the logarithm of skinfold measurements in order to achieve a linear relationship with body density.
Sex-dependent calibration factor of a whole-body radiation counter.
  • L. Burkinshaw
  • Medicine
    The International journal of applied radiation and isotopes
  • 1978
The use of body hydrogen as an internal standard in the measurement of nitrogen in vivo by prompt neutron capture gamma-ray analysis
The previously established technique of analysis of neutron capture γ-rays for the determination of nitrogen in-vivo has been modified to make estimates of absolute quantities of nitrogen mass.
...
...