Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK).

@article{Tosca2007EffectsOM,
  title={Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK).},
  author={Lucie Tosca and Christine Chabrolle and Svetlana Uzbekova and Jo{\"e}lle Dupont},
  journal={Biology of reproduction},
  year={2007},
  volume={76 3},
  pages={368-78}
}
In mammals, IGFs are important for the proliferation and steroidogenesis of ovarian cells. Metformin is an insulin sensitizer molecule used for the treatment of the infertility of women with polycystic ovary syndrome. It is, however, unclear whether metformin acts on ovarian cells. Adenosine 5' monophosphate-activated protein kinase (AMPK) is involved in metformin action in various cell types. We investigated the effects of metformin on bovine granulosa cell steroidogenesis in response to IGF1… CONTINUE READING

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