Effects of metabolic alterations on dopamine release in an in vitro model of neostriatal ischaemia

@article{Toner1999EffectsOM,
  title={Effects of metabolic alterations on dopamine release in an in vitro model of neostriatal ischaemia},
  author={Christopher C. Toner and Jonathan A. Stamford},
  journal={Brain Research Bulletin},
  year={1999},
  volume={48},
  pages={395-399}
}
Release of neurotransmitters, including dopamine (DA), plays a central role in neuronal death during cerebral ischaemia. We investigated the effects of changes in energy demand and supply on DA release in cerebral ischaemia in vitro. Rat striatal slices were superfused (400 ml/h) with an artificial cerebrospinal fluid at 34 degrees C, unless otherwise stated. Ischaemia were mimicked by removal of O2 and reduction in glucose concentration from 4 to 2 mM. DA release was monitored by voltammetry… CONTINUE READING
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