Effects of metabolic acidosis on intracellular pH responses in multiple cell types.

@article{Salameh2014EffectsOM,
  title={Effects of metabolic acidosis on intracellular pH responses in multiple cell types.},
  author={Ahlam Ibrahim Salameh and Vernon A. Ruffin and Walter F. Boron},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2014},
  volume={307 12},
  pages={R1413-27}
}
Metabolic acidosis (MAc), a decrease in extracellular pH (pHo) caused by a decrease in [HCO3 (-)]o at a fixed [CO2]o, is a common clinical condition and causes intracellular pH (pHi) to fall. Although previous work has suggested that MAc-induced decreases in pHi (ΔpHi) differ among cell types, what is not clear is the extent to which these differences are the result of the wide variety of methodologies employed by various investigators. In the present study, we evaluated the effects of two… CONTINUE READING
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